Topical Dutasteride

Now First Dual Acting 5-Alpha Reductase Inhibitor Available in TOPICAL compounded formulas

Medical Wellness Center is a leader in treating Men’s Hair Loss and first introduced Avodart (dutasteride) use as a medical breakthrough for Men’s Hair Loss in 2002.  Now Medical Wellness Center along with compounding pharmacy, Murray Avenue Apothecary**, is introducing a TOPICAL dutasteride formula.

  • Dutasteride is as safe as finasteride, but Dutasteride is MORE effective.
  • Dutasteride is the first and ONLY FDA-approved drug that inhibits both Type I & Type II 5-alpha reductase.
  • Finasteride only inhibits Type II 5 alpha reductase
    Type I & II 5 alpha reductase are the enzymes responsible for converting testosterone to DHT, the primary cause of male pattern hair loss.
  • Dutasteride reduces levels of DHT, but it does so to a greater extent than finasteride.
  • Dutasteride decreases DHT levels by 90%
  • Dutasteride is approved by FDA for prostate enlargement, just like Propecia’s (finasteride’s) parent drug, Proscar.

For over 20 years, Medical Wellness Center has been treating Male Pattern hair loss with exclusive formulations compounded by Murray Avenue Apothecary** (a privately owned Green pharmacy in Pittsburgh, PA).   You can choose either Compounded Topical Dutasteride 0.05% solution or Topical Dutasteride 0.05% solution with 5% Minoxidil.  We also offer up to 30% compounded minoxidil prescriptions, but these cannot be formulated with dutasteride. 

Topical Dutasteride is used in place of systemic Avodart (dutasteride) or finasteride (Propecia or Proscar).  Topical Dutasteride works alone or along with prescription strength compounded minoxidil formulations, Latisse, Nizoral Shampoo, and topical Spironolactone to enhance hair regrowth. 

Do NOT combine Topical Dutasteride with systemic Avodart (dutasteride) or systemic or topical  finasteride (Propecia or Proscar).

Topical Dutasteride REFILL consultation:  For returning Dutasteride Medical Wellness Center clients only.

IMPORTANT WARNING:  Dutasteride is for MEN ONLY!  NO Woman or child should ever take Avodart or dutasteride.  Pregnant or potentially pregnant women should not handle or touch Avodart  (dutasteride) and especially broken pills.  Absorbing the active ingredient in Avodart by a woman pregnant with a male baby, could result in abnormalities in the male baby’s sex organs 
IMPORTANT WARNING:  Topical Dutasteride can transfer by bedding or touch – Avoid touching areas until completely dry
IMPORTANT WARNING: Avodart after 6 months of usage decreased PSA levels used for Prostate cancer detection by 50%.  Men taking Avodart must inform all treating physicians and appropriate adjustments need to be made when monitoring PSA levels for cancer-related changes

MEDICAL WELLNESS CENTER PROVIDES:

  • Compounded Topical Dutasteride Hair Loss Prescriptions FOR MEN ONLY
  • Simple, Convenient, Confidential Online Physician Consultations for Topical Dutasteride Prescription for the Off-Label treatment of Male Pattern Hair Loss.
  • RISK-FREE Online Physician Evaluation to determine eligibility.
  • If approved the medical consultation fee is only $49.95 and your prescription will be forwarded to Compounding pharmacy, Murray Avenue Apothecary plus 6 additional refills.
  • Our exclusive Topical Dutasteride formulations are compounded by Murray Avenue Apothecary**. Select either Compounded Topical Dutasteride 0.05% solution or Topical Dutasteride 0.05% solution with 5% Minoxidil.  We also offer up to 30% compounded minoxidil prescriptions, but these cannot be formulated with dutasteride.
  • If you do not qualify for a Topical Dutasteride prescription, your visit is FREE.
    Do NOT combine topical dutasteride with either oral Avodart (dutasteride) or oral or topical Propecia/Proscar (finasteride) 
  • Express Service Available: Your Topical Dutasteride prescription will be forwarded to Murray Avenue Apothecary compounding pharmacy within approximately 24 hours.

HOW TO REQUEST A PHYSICIAN CONSULTATION FOR A TOPICAL DUTASTERIDE PRESCRIPTION:

  1. Read About Topical Dutasteride compounded formulations to learn more about its indications and contraindications.
  2. Read and Agree to the Waiver of Liability.
  3. Accurately and truthfully complete and submit a medical consultation questionnaire
  4. Your medical consultation will be reviewed by one of our Physicians and if approved you will be prescribed Topical Dutasteride. This consultation is RISK-FREE, if the physician determines Topical Dutasteride is not appropriate for you, then there is no charge.
  5. You can select either “regular” service (3-7 days to process) or “express” 24 hour processing for an express service fee.
  6. If approved you will receive an email confirmation from Medical Wellness Center, you prescription will be faxed to Murray Avenue Apothecary, and you will be contacted by Murray Avenue Apothecary for payment and shipping of the medication.
  7. If you have any health concerns in any way, you should contact your own physician for further advice.

The initial consultation fee for the physician evaluation is only $49.95 plus processing if you are approved for treatment, otherwise it’s free. If you find  Topical Dutasteride is working for you, yearly medical refill consultations are only  $75.00 plus processing for one year of refills.  Medical Wellness Center’s Online Topical Dutasteride Rx Consultation makes it easy for you to safely and effectively treat male pattern baldness from the convenience and privacy of your PC without  time-consuming and costly doctor visits.

Topical Dutasteride: FAQ

     WHAT IS MALE PATTERN HAIR LOSS?

    Male pattern baldness,  androgenetic alopecia,  is a very common condition in which men begin to experience thinning of the hair on the scalp.  These changes often start slowly in men in their 20’s and often progress to a receding hairline and/or balding on the top of the head.  Male pattern baldness is believed to be hereditary and dependent on hormonal effects. The primary cause of Male Pattern hair loss and baldness is due to Dihydrotestosterone (DHT) which is produced by 5-alpha reductase conversion of testosterone to DHT.

    WHAT IS DUTASTERIDE? HOW DOES IT COMPARE TO PROPECIA – FINASTERIDE?

    Dutasteride was the FIRST  dual acting 5 alpha reductase inhibitor blocking both Type I and Type II 5-alpha reductase enzymes that convert testosterone to DHT.  Propecia (finasteride), the oral drug approved by the FDA to treat male pattern baldness, only inhibits Type II 5 alpha reductase enzyme. Men with male pattern baldness have increased levels of the hormone DHT and the hair follicles in the balding areas of the scalp become miniaturized. Like finasteride, DUTASTERIDE  interrupts a key factor in the development of androgenetic or male pattern baldness but to an even greater extent.  Dutasteride at a daily dosage of 0.5mg/ day has been shown to reduce serum levels of DHT by over 90%.   Like finasteride, the active ingredient in Propecia, dutasteride or Avodart has initially been approved by the FDA for the treatment of prostatic enlargement   Preliminary studies have shown Dutasteride to be as SAFE as Propecia but significantly more effective in decreasing DHT levels and treating Male Pattern Baldness.

    WHAT IS THE DIFFERENCE BETWEEN AVODART (Dutasteride) PILLS vs TOPICAL DUTASTERIDE?

    Since 2002 our patients have experienced the benefits of oral Avodart (dutasteride) with most patients not experiencing any significant side effects.  But as with all medications, there are potential side effects from temporary reversible sexual side effects to more lasting ones such as gynecomastia.  This has lead to the development of a topical dutasteride formulation with the intent of markedly reducing potential side effects.

    CAN TOPICAL DUTASTERIDE BE COMPOUNDED WITH MINOXIDIL or OTHER ADDITIVES?

    All exclusive compounded formulations are compounded by Murray Avenue Apothecary due to their highest standards of production. Topical Dutasteride is compounded as a 0.05% Dutasteride solution or it can be compounded only with 5% minoxidil.  We do offer compounded minoxidil formulations up to 30% with additives.  If you want to combine a Topical Dutasteride solution and a higher strength minoxidil, we recommend two separate solutions to produce a product with highest integrity and stability.  You can check out our high prescription strength minoxidil formulations.

    CAN TOPICAL DUTASTERIDE USED SIMULTANEOUSLY ALONG WITH OTHER TOPICAL HAIR LOSS TREATMENTS?

    Yes. Although you can not simultaneously use more than one 5 alpha-reductase inhibitor  (Finasteride or Dutasteride), combining multiple modalities to treat male pattern hair loss markedly improves response and hair retention regrowth.   Topical dutasteride can be used simultaneously along with Latisse or latanoprost, prescription strength minoxidil formulations, Topical Spironlactone, Nizoral shampoo etc.

    WILL DUTASTERIDE WORK FOR ME?   WHAT ARE THE INDICATIONS?

    Dutasteride has been shown in preliminary Phase 2 studies by GlaxoSmithKline to be more effective than Propecia for Male Pattern Hair loss. In over 80% of Men with Male pattern baldness in the vertex and anterior mid-scalp area, clinical  studies have shown that Propecia stops further hair loss and/or increases the number of scalp hairs resulting in significant hair re-growth filling in thin or balding areas of the scalp.  Medical Wellness Center has been compiling Patient responses to Dutasteride. Click here to read unedited patient responses to Dutasteride.

    HOW LONG BEFORE I SEE RESULTS?

    Hair grows only about 1 inch per month, therefore patients start to notice results after first 3 months of treatment. It takes time to see improvement.  Also, for those just starting to have hair thinning, taking Avodart in the early stages can prevent or dramatically slow further hair loss.

    HOW LONG DO I HAVE TO TAKE DUTASTERIDE?

    The underlying predisposition to baldness is always present. Therefore, if a patient discontinues use of  Dutasteride, he will gradually lose the new hair that grew in response to Dutasteride treatment and will experience the progression of his underlying predisposition to baldness.

    WHEN AND HOW DO I USE TOPICAL DUTASTERIDE?

    Topical Dutasteride is dosed equivalent to the oral Avodart prescribed dose of 0.5mg soft gelatin capsules which is taken once a day. Topical Dutasteride is compounded in a 0.05% solution and you apply 1 ml once daily. Using Topical Dutasteride more frequently or in higher doses will NOT make it work better or faster, and can result in potentially irreversible and even fatal side effects.  If you miss a dutasteride dose, take the missed dose as soon as you remember during the SAME day. However, if you don’t remember until the next day, skip the dose you missed and take only the next regularly scheduled dose. DO NOT take a double dose of the medication.

      1. Dutasteride is for use by MEN only
      2. Make sure your scalp is completely dry before applying.
      3. Wash hands immediately after applying
      4. Avoid touching scalp until completely dry, allow 2-4 hours to completely dry.
      5. WARNING: if not completely dry may transfer formula to other areas or to clothing or bedding
      6. Do NOT shampoo hair for 4 hours after applying.
      7. WARNING: Dutasteride and finasteride are absorbed through skin and Pregnant woman should NOT come in contact with Dutasteride or Finasteride pills or topical formulations, can cause birth defects male fetus.
      8. Always discuss any new medications with your primary care physician first before taking.
      9. Do NOT combine Dutasteride with finasteride – Proscar or Propecia. Do NOT combine Topical Dutasteride with either topical finasteride or with Dutasteride (Avodart) or Propecia/Proscar (finasteride) pills.

    WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT ABOUT DUTASTERIDE?

    • Dutasteride is for MEN only
    • Dutasteride is a more potent and effective 5 alpha reductase inhibitor than Propecia (finasteride). Although Avodart (dutasteride) was approved in October 2002 by the FDA for treatment of prosthetic enlargement (BPH), dutasteride  has been shown to be more effective than Propecia (finasteride) in treating male hair loss and can be prescribed off-label for other indications than BPH.
    • Pregnant women or women who may become pregnant MUST NOT handle Avodart(dutateride) capsules or solution nor come in contact by transference, as dutasteride can be absorbed via the skin and cause external genital abnormalities in the male fetus.
    • Do not donate blood for at least 6 months after your last dose of Dutasteride to prevent pregnant woman receiving dutasteride via blood transfusion.
    • Store Dutasteride at room temperature away from moisture and heat.
    • Dutasteride reduces the serum level of the Prostate cancer marker PSA by approximately 40% after 3 months of treatment and by 50% after 6 months of treatment.  Therefore, if taking Dutasteride one must inform all treating physicians and adjustments need to be made in baseline measurements and interpretation of PSA levels for monitoring cancer-related changes.  To interpret PSA testing for a man on Dutasteride treatment for 6 months or longer, one must double the PSA value for Prostate cancer detection.

    CAN TOPICAL DUTASTERIDE BE USED ALONG WITH ORAL DUTASTERIDE OR FINASTERIDE

    Topical Dutasteride musts NOT be combined with ORAL dutasteride (Avodart)
    Topical Dutasteride must NOT be combined with either Oral Finasteride (Propecia or Proscar)  or Topical Finasteride

    WHAT ARE THE SIDE EFFECTS OF DUTASTERIDE?

    Oral Dutasteride has shown a similar safety profile as Propecia and most men, as with Propecia, experience no side effects.  A small percentage of men experience the following side effects most of which decrease or disappear with continued usage: impotence (4.7%), decreased libido (3%), breast tenderness and breast enlargement (0.5%) and ejaculation disorders (1.4%).   These possible side effects disappeared in most men who continued to take Avodart  and completely disappeared in men who stopped taking Avodart.Stop using Dutasteride and seek emergency medical attention if you experience an allergic reaction such as difficulty breathing, closing of the throat, swelling of the lips, tongue or face

    WHO SHOULD NOT USE TOPICAL DUTASTERIDE?

    • Do  NOT use Topical Dutasteride if you are a female or under age 18.
    • Do NOT use Topical Dutasteride if you have LIVER disease because Dutasteride is metabolized by the liver.
    • Do NOT use Topical Dutasteride if you are taking Protease Inhibitors such as Agenerase (amprenavir), Crixivan (indinavir), Viracept (nelfinavir), Novir (ritonavir) or Inervase, Fortovase (saquinavir).
    • Do NOT use Topical Dutasteride if you are taking ORAL Nizoral (ketaconazole) or Sporanox (itraconazole) or ORAL Avodart (dutasteride) or ORAL Propecia (finasteride).
    • Do NOT use Topical Dutasteride if you are using topical finasteride.
    • Women who are pregnant or planning to become pregnant must NOT touch Avodart (dutasteride) capsules  or come in contact directly or indirectly by transference with topical dutasteride solution.  Dutasteride can be absorbed through the skin and cause harm to a developing male fetus. Therefore, Men whose wife is pregnant or trying to become pregnant should not use topical dutasteride due to possible transference.

    In order to proceed to the medical consultation, you must go to the next section and read the complete list of contraindications. Then you must verify that you do not have any of the contraindications, and understand that any pregnant or potentially pregnant woman must not even touch any broken or crushed pills or come in contact with topical dutasteride solution. Under NO circumstance is any woman or a child under the age of 18 to use Topical Dutasterideyou are not pregnant and are not breast feeding. 

    Before Proceeding to the Medical Consultation Form  please read

    CONTRAINDICATIONS, PRECAUTIONS and WARNINGS
    and accept the Waiver of Liability

    CONTRAINDICATIONS:

    • Anyone with any liver function abnormalities, liver disease, hepatitis or any other medical disorder of liver function including but not limited to cirrhosis of the liver, liver cancer, jaundice etc. should not take Avodart. If you have any questions about your medical condition, consult your primary care physician before taking Avodart.
    • Do NOT use Topical Dutasteride if you are taking potent Protease Inhibitors: Agenerase (amprenavir), Crixivan (indinavir), Viracept (nelfinavir), Norvir (ritonavir) or Invirase or Fortovase (saquinavir).**
    • Do NOT use Topical Dutasteride if you are taking oral Avodart (dutasteride) or oral Propecia or Proscar (finasteride) or using topical finasteride or oral ketoconazole (Nizoral) or Sporanox (Itraconazole).**
    • Do NOT use Topical Dutasteride if you are allergic to Propecia, Proscar or Finasteride or Avodart or dutasteride
    • Absolutely no one under the age of 18 should take Avodart.
    • Absolutely no female should take Avodart under any circumstances.
    • Do NOT combine Topical Dutasteride with Topical or Oral Avodart with Propecia or Proscar (finasteride)

    **Dutasteride is metabolized by human cytochrome P45 isoenzyme CYP3A4. There are no clinical studies to evaluate the impact of CYP3A4 enzyme inhibitors on dutasteride pharmacokinetics. However, based on in vitro data blood concentrations of dutasteride may increase in the presence of POTENT inhibitors of CYP3A4 such as potent protease inhibitors, ketoconazole, itraconazole… Therefore there is a potential for drug-drug interaction of dutasteride and systemic chronic dosing with potent CYP3A4 inhibitors. In otherwise healthy individuals with no liver disease, topical applications would not indicate as much caution and would not be a contraindication to dutasteride, only systemic ORAL ketoconazole or other CYP3A4 inhibitors would be a contraindication.

    IMPORTANT WARNING:

    Pregnant or potentially pregnant woman should not touch or come in contact with topical Dutasteride or Avodart capsules and should definitely NOT touch broken or crushed capsules. If pregnant with a male baby and the pregnant woman is exposed to the active ingredient in Avodart, the male baby could be born with abnormalities of the male sex organs.
    Men using Topical Dutasteride or oral Avodart should NOT donate blood for at least 6 months after last dose to prevent transmission of dutasteride to a pregnant woman via blood transfusion

    DUTASTERIDE SIDE EFFECTS:

    The majority of Men using oral Avodart experience no side effects. Side effects are similar to Propecia side effects and are usually mild to moderate and tend to go away during treatment course: Impotence (4.7%), decreased libido (3%), breast tenderness and breast enlargement (0.5%) and ejaculation disorders (1.4%). The incidence of most drug-related adverse events decreased with duration of treatment. Topical Dutasteride decreases possible incidence of any of these side effects
    Rarely allergic reactions – seek immediate emergency medical attention

    IMPORTANT INFORMATION:

    Dutasteride can affect the blood test for the screening of Prostrate Cancer, the PSA (Prostate-Specific Antigen). It is very important that if you have a PSA test done, you need to tell your doctor that you are using Topical Dutasteride. Dutasteride has no effects on prostate cancer nor is it associated with cancer, it just can affect the reading of the test results. Therefore, in order to have an accurate screening test, the doctor must be aware that you are taking Avodart. After 6 months of using Avodart one’s PSA levels can be decreased by as much as 50% and it important to double the value when testing PSA for prostate cancer detection or following PSA levels for monitoring. Topical Dutasteride may also affect PSA tests, but probably to a lesser extent.

    DUTASTERIDE PRESCRIBING INFORMATION:

    Oral Avodart has only been approved by the FDA for the treatment of prostatic enlargement and although it has been tested and shown to be more effective than Propecia for hair loss it has not yet been approved as a treatment for hair loss. Medical Wellness Center has been prescribing oral Avodart since 2002. Dutasteride is a more potent 5-alpha reductase enzyme inhibitor than Propecia and decreases serum DHT levels responsible for Male Pattern Hairloss. Therefore Medical Wellness Center is off-label prescribing oral Avodart and Topical Dutasteride for Male Pattern Hair Loss Only. We do NOT prescribe Avodart for BPH (prostatic enlargement) as this condition needs close physician monitoring to prevent or detect the progression to Prostate cancer. Topical Dutasteride or oral Avodart prescribed for Male Pattern Hair Loss is NOT covered by insurance.

    I DO NOT HAVE ANY OF THE ABOVE CONTRAINDICATIONS:

    In order for Medical Wellness Center Physicians to provide you with the best care you need to reply honesty to all questions and you need to understand any and all risks and side effects associated with Dutasteride.

    By accepting “I Agree” means that you have read the above contraindication and warnings and honestly acknowledge that you do not have any of the above contraindications to Topical Dutasteride therapy and understand that insurance will not cover the cost of the medication. Also, I am aware that I need to inform my doctor that I am using Topical Dutasteride if I have a PSA blood test.

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      **Medical Wellness Center is not affiliated or associated with Murray Avenue Apothecary.  Murray Avenue Apothecary is a privately owned pharmacy and is completely independent of Medical Wellness Center.   Medical Wellness Center provides customized treatments based on almost 20 years experience treating male pattern hair loss, and they forward all compounded hair loss prescriptions exclusively to Murray Avenue Apothecary because of the integrity and reliability of this United States based, privately owned, local pharmacy; the experience of Susan Merenstein, the compounding pharmacist; and that this pharmacy only uses FDA approved ingredients.

      1: LinksStough D. 

      Dutasteride improves male pattern hair loss in a randomized study in identical twins.
      J Cosmet Dermatol. 2007 Mar;6(1):9-13.
      PMID: 17348989 [PubMed – indexed for MEDLINE]

      2: LinksOlsen EA, Hordinsky M, Whiting D, Stough D, Hobbs S, Ellis ML, Wilson T, Rittmaster RS; Dutasteride Alopecia Research Team.

      The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride.
      J Am Acad Dermatol. 2006 Dec;55(6):1014-23.
      PMID: 17110217 [PubMed – indexed for MEDLINE]

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      IMPORTANT NOTE: This is a summary and does not contain all possible information about this product. For complete information about this product or your specific health needs, ask your health care professional. Always seek the advice of your health care professional if you have any questions about this product or your medical condition. This information is not intended as individual medical advice and does not substitute for the knowledge and judgment of your health care professional. This information does not contain any assurances that this product is safe, effective, or appropriate for you.